Design, Synthesis, and Biological Activity Study of a New Triphenylamine Photosensitizer

本文采用电子供体与受体芳香环的共轭连接设计并合成了一种新型三苯胺型聚集诱导发光型光敏剂，并进行理化性质研究以及生物活性研究。试验结果表明新光敏剂具有高效、低毒的特性，其优异的活性氧生成能力为光动力治疗提供了新工具。未来，通过波长拓展、纳米递送、联合治疗等策略，有望推动此类光敏剂向临床转化，最终实现肿瘤精准治疗的重大突破。光敏剂的“智能化”与“多功能化”将成为下一代光动力治疗研究的核心方向。This article uses conjugated connections between electron donors and acceptor aromatic rings to design and synthesize a novel triphenylamine based aggregation induced luminescent photosensitizer with high reactive oxygen species generation rate. Physical and chemical properties as well as biological activity were studied. The experimental results indicate that the new photosensitizer has the characteristics of high efficiency and low toxicity, and its excellent ability to generate reactive oxygen species provides a new tool for photodynamic therapy. In the future, strategies such as wavelength expansion, nano delivery, and combination therapy are expected to promote the clinical translation of such photosensitizers, ultimately achieving a major breakthrough in precision cancer treatment. The “intelligence” and “multifunctionality” of photosensitizers will become the core direction of next-generation photodynamic therapy research.