Unraveling Genetic Versus Environmental Factors Determining Disease Course in Inflammatory Bowel Diseases: A Population-Based Cohort Study in First- and Second-Generation Immigrants
Disease outcomes change across immigrant generations, pointing to environmental factors possibly impacting disease course, which needs further investigation. In contrast, non-Western immigrants were shown to have more perianal disease in both generations, suggesting a genetic susceptibility for this debilitating phenotype.
Authors
- Severine A.R.A. Vermeire (ORCID: https://orcid.org/0000-0001-9942-3019)
- Parul Tandon (ORCID: https://orcid.org/0000-0003-0021-2161)
- Bram Verstockt (ORCID: https://orcid.org/0000-0003-3898-7093)
- Tine Jess (ORCID: https://orcid.org/0000-0002-4391-7332)
- Nynne Nyboe Andersen (ORCID: https://orcid.org/0000-0003-0874-0356)
- Anna-Teresa D’Hooghe (ORCID: https://orcid.org/0009-0005-1574-6352)
- Gry Poulsen (ORCID: https://orcid.org/0000-0003-2744-2469)
- Christian Nikolai Sørensen (ORCID: https://orcid.org/0009-0000-6944-4329)
Institutions
- University Health Network (CA)
- University of Toronto (CA)
- Aalborg University Hospital (DK)
- Zealand University Hospital (DK)
- Predict (France) (FR)
- Zealand University Hospital Køge (DK)
- Aalborg University (DK)
- KU Leuven (BE)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1093/ibd/izaf128
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Danmarks Grundforskningsfond
- KU Leuven