Temsirolimus, a water-soluble mTOR inhibitor, alleviates osteoarthritic changes in human chondrocytes and mouse osteoarthritis models
Temsirolimus treatment protected human chondrocytes from IL-1β-induced OA gene expression changes and apoptosis. Intra-articular injection of temsirolimus delayed OA progression in the mouse OA model and in SAMP8 mice. Thus, the intra-articular administration of temsirolimus is a promising therapeutic approach to inhibit articular cartilage degradation.
Authors
- Naosuke Nagata (ORCID: https://orcid.org/0000-0001-9363-9994)
- Kanto Nagai (ORCID: https://orcid.org/0000-0002-8996-0299)
- Yuichi Hoshino (ORCID: https://orcid.org/0000-0001-6142-8973)
- Takehiko Matsushita (ORCID: https://orcid.org/0000-0001-6616-0398)
- Kiminari Kataoka
- Tomoyuki Matsumoto (ORCID: https://orcid.org/0000-0003-4587-0029)
- Noriyuki Kanzaki (ORCID: https://orcid.org/0000-0002-9771-7205)
- Shohei Sano
- Kyohei Nishida
- Nobuaki Miyaji (ORCID: https://orcid.org/0000-0002-5024-5343)
- Tetsuya Yamamoto (ORCID: https://orcid.org/0000-0002-9998-3427)
- Akiyoshi Mori (ORCID: https://orcid.org/0000-0003-0751-9625)
- Ryosuke Kuroda (ORCID: https://orcid.org/0000-0001-5097-7264)
- Yoshihiro Otsuki
Institutions
- Kobe University (JP)
Publication Details
- Journal
- Connective Tissue Research
- Published
- 2025-06-29
- DOI
- https://doi.org/10.1080/03008207.2025.2521404
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science