Selective and Adaptive Targeted Approach to Influence Genomics and Epigenomic Signature in Lung Cancer

Application of single targeted therapies in cancer has caused resistance in tumors, especially the heterogeneous tumors such as lung cancer. Here we propose a different strategy in approaching heterogeneous tumors, looking at a sequential but systemic and pan-genomic targeted therapy through epigenetic modifications. We aim to trigger new hypotheses and generate provoking scientific methods to address current challenges in oncology care