Effects of a Combined Collagen Stimulation Procedure Consisting of 675 nm Laser Device and Hyaluronic Acid-Based Filler Injections for Facial Rejuvenation

<b><i>Background:</i></b> There has been an increase in interest in using in-office cosmetic treatments to promote collagen in the skin and deeper tissues. <b><i>Aim:</i></b> The current study assesses the safety and efficacy of the combination of a 675 nm laser wavelength and the injection of soft tissue fillers based on hyaluronic acid (HA) during facial rejuvenation treatments. <b><i>Materials and methods:</i></b> A total of 16 patients treated for facial skin rejuvenation and reduction of facial laxity were divided into two groups: Group 1 underwent three sessions of a 675 nm laser system combined with three sessions of HA filler and Group 2 received three sessions of the 675 nm laser system alone. One treatment every 30 days for 3 months was performed. Images were acquired at baseline (T₀), after the second session (T_m), and 1 month after the last treatment (T_f). A dermal analysis system was employed for skin analysis. The 10-point visual analog scale and the 5-point Global Aesthetic Improvement Scale (GAIS) were used. <b><i>Results:</i></b> In both groups, but more promisingly in Group 1, the skin showed an improvement in its elasticity reported with an increase in Young's modulus, a decrease in retraction time, and an increase in viscoelasticity. Qualitative analysis of high-frequency dermal ultrasound images showed significant increases in new collagen density and dermal thickness. These results were confirmed with the GAIS. No side effects were recorded. <b><i>Conclusion:</i></b> The findings indicate that the combination of 675 nm laser and HA filler was well-tolerated and safe and has shown promising results for treating skin aging.