Contribution of Polygenic Scores to Progression Independent of Relapse Activity in Multiple Sclerosis
Our results suggest an influence of severity-related genetic load on the rate of PIRA events, especially in subjects with disease onset before the age of 50 years, characterized by a less prominent effect of aging processes on disability accumulation. This finding supports previous observations from other studies of an age-dependent influence of genetic risk scores on complex traits.
Authors
- Federica Esposito (ORCID: https://orcid.org/0000-0003-2550-0805)
- Massimo Filippi (ORCID: https://orcid.org/0000-0002-5485-0479)
- Lucia Moiola (ORCID: https://orcid.org/0000-0001-6313-4952)
- Antonino Giordano (ORCID: https://orcid.org/0000-0002-3685-8311)
- Ferdinando Clarelli (ORCID: https://orcid.org/0000-0001-9561-4360)
- Melissa Sorosina (ORCID: https://orcid.org/0000-0003-4376-2550)
- Mariangela Tuzzolo Missaglia
- Elisabetta Mascia (ORCID: https://orcid.org/0009-0000-9776-7854)
- Maria Assunta Rocca (ORCID: https://orcid.org/0000-0003-2358-4320)
- G. Visentin
Institutions
- Vita-Salute San Raffaele University (IT)
- Neuroscience Institute (IT)
- IRCCS Ospedale San Raffaele (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
Publication Details
- Journal
- European Journal of Neurology
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1111/ene.70264
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00