Development and External Validation of a Genetic Risk Score for Pain in Rheumatoid Arthritis
GRS based on pain-related SNPs were associated with RA pain and disease activity, suggesting that the genetic risk of pain may have clinical impacts in RA, such as the likelihood of achieving remission.
Authors
- Katherine D. Wysham (ORCID: https://orcid.org/0000-0001-8707-7649)
- Michael March (ORCID: https://orcid.org/0000-0001-9173-6862)
- Austin M. Wheeler (ORCID: https://orcid.org/0000-0002-8816-7782)
- Kaleb Michaud (ORCID: https://orcid.org/0000-0002-5350-3934)
- Rachel L. Kember (ORCID: https://orcid.org/0000-0001-8820-2659)
- Rui Xiao (ORCID: https://orcid.org/0000-0002-2727-8171)
- Sylvanus Toikumo (ORCID: https://orcid.org/0000-0002-6024-0693)
- Brian C. Sauer (ORCID: https://orcid.org/0000-0002-3546-3051)
- Katie J. McMenamin (ORCID: https://orcid.org/0000-0002-5483-9122)
- Kristin Wipfler (ORCID: https://orcid.org/0000-0001-8137-8117)
- Ted R. Mikuls (ORCID: https://orcid.org/0000-0002-0897-2272)
- Bryant R. England (ORCID: https://orcid.org/0000-0002-9649-3588)
- Grant W. Cannon (ORCID: https://orcid.org/0000-0001-6640-9173)
- Joshua F. Baker (ORCID: https://orcid.org/0000-0003-0170-028X)
- Thomas R. Riley (ORCID: https://orcid.org/0009-0003-0194-7562)
- Henry R. Kranzler
Institutions
- Boston University (US)
- Boston Medical Center (US)
- Children's Hospital of Philadelphia (US)
- University of Utah (US)
- University Medical Center (US)
- VA Puget Sound Health Care System (US)
- Lake City VA Medical Center (US)
- The National Databank for Rheumatic Diseases (US)
- Philadelphia VA Medical Center (US)
- VA Nebraska Western Iowa Health Care System (US)
- University of Nebraska Medical Center (US)
Publication Details
- Journal
- Arthritis Care & Research
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1002/acr.25588
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00