High matrix metalloproteinase-2 expression predicts poor prognosis of colon adenocarcinoma and is associated with PD-L1 expression and lymphocyte infiltration
This work shows for the first time that MMP-2 not only contributes to tumor progression but also plays a critical role in the immunosuppressive microenvironment of COAD. The demonstrated association between MMP-2 and PD-L1 expression, along with its effect on TILs, indicates that MMP-2 is a promising alternative target for improving the efficacy of anti-PD-L1 immunotherapy. Targeting MMP-2 may offer a novel avenue for overcoming resistance to conventional immunotherapies, potentially improving treatment outcomes in COAD patients.
Authors
- Yang-lin Zhu (ORCID: https://orcid.org/0000-0003-4842-4112)
- Yafei Qin (ORCID: https://orcid.org/0000-0002-0063-4551)
- Yongjie Xie (ORCID: https://orcid.org/0009-0003-3595-0866)
- Chenglu Sun (ORCID: https://orcid.org/0000-0001-9927-9344)
- Shaohua Ren (ORCID: https://orcid.org/0000-0002-4400-9045)
- Dejun Kong (ORCID: https://orcid.org/0000-0002-6878-9293)
- Guangming Li (ORCID: https://orcid.org/0000-0003-2286-7679)
- Hongda Wang (ORCID: https://orcid.org/0000-0003-2654-261X)
- Hao Wang (ORCID: https://orcid.org/0000-0002-2438-6732)
- Hao Jing-peng
- Bo Shao (ORCID: https://orcid.org/0000-0003-2394-5050)
- Hong Qin (ORCID: https://orcid.org/0000-0002-2806-4546)
- Yiyi Xiao
Institutions
- China Three Gorges University (CN)
- Nankai University (CN)
- Wenzhou Medical University (CN)
- Tianjin Medical University General Hospital (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Second Hospital of Tianjin Medical University (CN)
- Henan Provincial People's Hospital (CN)
- Jinhua Central Hospital (CN)
- Inner Mongolia Medical University (CN)
- Tianjin Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2025-06-30
- DOI
- https://doi.org/10.7717/peerj.19550
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Tianjin City