Discovery and evaluation of novel pyrrole/thiophene chalcone urea EGFR inhibitors via biological and docking studies
Several chalcone-urea derivatives demonstrated potent anticancer properties, with compound 5c emerging as a promising EGFR inhibitor with strong cytotoxic and pro-apoptotic effects.
Authors
- Belma Zengin Kurt (ORCID: https://orcid.org/0000-0002-4663-5402)
- Yakup Kolcuoğlu (ORCID: https://orcid.org/0000-0002-4611-2433)
- Ahmet Fatih Şahin (ORCID: https://orcid.org/0000-0001-7802-8730)
- Atilla Akdemir (ORCID: https://orcid.org/0000-0001-8416-0471)
- Dilek Öztürk Civelek (ORCID: https://orcid.org/0000-0003-2485-891X)
- Zeynep Durukan
- Hümeyra Şahin Bektay (ORCID: https://orcid.org/0000-0001-6748-751X)
- Fatih Sönmez (ORCID: https://orcid.org/0000-0001-7486-6374)
- Ayşegül Özbilge Ulueren
Institutions
- Sakarya University (TR)
- Karadeniz Technical University (TR)
- Bezmiâlem Vakıf Üniversitesi (TR)
- Istanbul University-Cerrahpaşa (TR)
- Istinye University (TR)
- Sakarya Uygulamalı Bilimler Üniversitesi
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1080/17568919.2025.2521249
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu