Lymphocytic Pleural Effusion Due to Crizotinib Usage

A 41-year-old woman with Anaplastic Lymphoma Kinase (ALK) gene positive adenocarcinoma of the lung presented with dyspnea in the 4th month of Crizotinib therapy with a prominent finding of bilateral mild pleural effusion.A comprehensive radiological and laboratory investigation discounted infection, rheumatological diseases and malignancies, while the symptoms and pleural effusion regressed after pausing Crizotinib medication.We present this unusual case of lymphocytic pleural effusion associated with Crizotinib, which is a novel tyrosine kinase inhibitor.