Association Study Among Double/Triple Expressor Status, Extranodal Involvement, and Hans Subtype in Diffuse Large B-cell Lymphoma

Background: Investigating the Association of Double/Triple Expression with Extranodal Involvement and Hans Classification, and Analyzing the Relationship between Molecular Genetic Characteristics and Clinicopathological Characteristics in DLBCL. Methods: A retrospective analysis of clinical data from 54 patients diagnosed with diffuse large B-cell lymphoma (DLBCL) at Baotou Cancer Hospital between January 2020 and June 2024 was conducted to examine the associations of genetic subtypes with clinical features including extranodal involvement and Hans classification. Results: The double/triple expression group exhibited a significantly higher rate of extranodal involvement than the non-double/triple expression group (76.0% vs. 41.4%; P = 0.014), and the prevalence of double/triple expression was significantly higher in the non-GCB subtype compared to the GCB subtype (60.0% vs. 29.2%; P = 0.024). Conclusions: Double/triple-expressor DLBCL exhibits a more aggressive biological behavior, predisposes to extranodal involvement, and is closely associated with the non-GCB subtype. These findings reveal the molecular heterogeneity of diffuse large B-cell lymphoma (DLBCL) and provide a scientific foundation for its precision treatment and prognostic assessment.