Decarboxylative Alkylation of Difluoroenoxysilanes via Visible Light‐Excited Electron Donor–Acceptor Complex

This study presents a visible‐light‐driven, photocatalyst‐free method for synthesizing α,α ‐difluoroketones via electron donor–acceptor (EDA) complex activation. Using cost‐effective aliphatic carboxylic acid derivatives redox‐active esters, the protocol enables decarboxylative difluoroalkylation under mild conditions, achieving high yields (up to 94%) with triphenylamine. Mechanistic studies confirm radical intermediates and a 1:1 EDA complex stoichiometry. The method demonstrates broad substrate scope and successful late‐stage drug modifications, offering a sustainable approach to fluorinated bioactive compounds.