Mitochondrial Tumor Suppressor 1A Attenuates Myocardial Infarction Injury by Maintaining the Coupling Between Mitochondria and Endoplasmic Reticulum
Our study demonstrates that Mtus1A is crucial for modulating MI-induced cardiac remodeling by preserving ER-mitochondria communication and ameliorating mitochondrial function in cardiomyocytes. Mtus1A may serve as a potential therapeutic target for treating heart failure after MI.
Authors
- Zhida Shen (ORCID: https://orcid.org/0000-0001-7068-8689)
- Qinfeng Li (ORCID: https://orcid.org/0000-0003-0582-2102)
- Dongwu Lai
- Yinfang Wang
- Luyang Yu (ORCID: https://orcid.org/0000-0002-1301-6285)
- Chenyang Jiang (ORCID: https://orcid.org/0000-0002-0199-3353)
- Lenan Zhuang (ORCID: https://orcid.org/0000-0001-9561-8396)
- Fuyu Qiu (ORCID: https://orcid.org/0000-0002-5957-1786)
- Xue Lü (ORCID: https://orcid.org/0000-0001-6530-0037)
- Yun Gao
- Xingchen Wang (ORCID: https://orcid.org/0000-0001-5316-789X)
- Jiawen Chen (ORCID: https://orcid.org/0000-0002-6022-9646)
- Guosheng Fu (ORCID: https://orcid.org/0000-0001-7027-0717)
- Jun Lin (ORCID: https://orcid.org/0000-0001-5583-895X)
- Yuhang Tao
- Yingchao Gong
- Peng Zhang (ORCID: https://orcid.org/0000-0002-1959-8482)
Institutions
- Sir Run Run Shaw Hospital (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
- Central Hospital of Putuo District (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Circulation
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1161/circulationaha.124.069737
- Citations
- 13
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 10.48