Retrospective Analysis of Modified Danggui Shaoyao Decoction in the Treatment of Qi and Yin Deficiency Syndrome of Primary Nephrotic Syndrome in Children

目的：初步探索加减当归芍药方治疗儿童原发性肾病综合征气阴两虚证的临床疗效及安全性。方法：采用回顾性分析，2022年10月~2024年12月期间在黑龙江省中医医院小儿肾病科门诊治疗的患儿中，选取诊断为原发性肾病综合征气阴两虚证，并经激素治疗 + 加减当归芍药方治疗4周、随访6个月的患儿58例，构建线性混合模型，观察患儿治疗前后中医证候总积分的差异、治疗后激素相关不良反应发生率及复发率和加减当归芍药方相关不良反应。结果：治疗后中医证候总积分较治疗前降低，差异有统计学意义(P Objective: To preliminarily evaluate the clinical efficacy and safety of modified Danggui Shaoyao Decoction in the treatment of qi and yin deficiency syndrome of primary nephrotic syndrome in children. Methods: A retrospective case-control study was conducted. From October 2022 to December 2024, 58 children diagnosed with primary nephrotic syndrome with deficiency of both qi and yin were selected from the outpatient department of pediatric nephrology in Heilongjiang Provincial Hospital of Traditional Chinese Medicine. They were treated with hormone therapy plus modified Danggui Shaoyao Decoction for 4 weeks and followed up for 6 months. Observe the difference of TCM syndrome scores before and after treatment, the incidence and recurrence rate of hormone-related adverse reactions after treatment, and the adverse reactions related to modified Danggui Shaoyao Fang. Results: After treatment, the scores of TCM syndromes were lower than those before treatment, and the difference was statistically significant (P < 0.05). The total effective rate of 58 children after treatment was 91.4%, and the recurrence rate was 10.3%. Among the hormone-related adverse reactions, Cushing-like manifestations accounted for 20.7%, respiratory tract infections accounted for 24.4%, and both accounted for 10.3%. There was no adverse reaction related to modified Danggui Shaoyao prescription. Conclusion: Modified Danggui Shaoyao Decoction has obvious advantages in reducing or avoiding hormone side effects, reducing or avoiding recurrence, and improving efficacy in children with PNS of Qi and Yin deficiency syndrome. It has rare adverse reactions and high safety.