Metformin efficacy and tolerance according to genetic polymorphisms of organic cation transporter 1 in Tunisian patients with type 2 diabetes
In Tunisian type 2 diabetes, the M420del and R61C do not appear to be associated with metformin efficacy or the gastrointestinal intolerance. However, the G401S polymorphism may be implicated in the occurrence of metformine-induced gastrointestinal adverse effects.
Authors
- Mériem Yazidi (ORCID: https://orcid.org/0000-0002-4239-5229)
- Mélika Chihaoui (ORCID: https://orcid.org/0000-0001-7991-9885)
- Fatma Chaker
- Moncef Feki (ORCID: https://orcid.org/0000-0003-1585-4052)
- Hiba Allah Chatti
- Nadia Khessairi
- Ibtissem Oueslati (ORCID: https://orcid.org/0000-0002-4278-9447)
- Ameni Kallel
Institutions
- Tunis El Manar University (TN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-06-30
- DOI
- https://doi.org/10.3389/fendo.2025.1536402
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00