Histopathological pattern of disease seen in patients undergoing endometrial biopsies - Two years study at a tertiary care hospital

Objective: The objective of the study was to analyse the spectrum of various histopathological patterns and frequencies of endometrial disorders, affecting the patients presenting with abnormal uterine bleeding, who underwent the procedure of endometrial biopsies. Material and Methods: This was a retrospective cross-sectional study, carried out at Histopathology department of Foundation University Medical College, Islamabad. Duration of study was two years which extended from June 2022 to May 2024. Results: A total number of 1835 of cases were analysed. The average age of patients was 29-76 years (4750). Main presenting complaint of the patients was abnormal uterine bleeding. The most common functional cause of AUB in our study was Disordered Proliferative Endometrium (18.80 %). The major organic cause was endometrial hyperplasia without atypia (21.25%). Majority of the patients belonged to perimenopausal age group. Conclusion: Endometrial biopsy remains the most important and least invasive procedure for diagnosing an underlying endometrial pathology till date. Disordered Proliferative Endometrium is the commonest cause of abnormal uterine bleeding specially in perimenopausal females. Keywords: Abnormal uterine bleeding, Disordered proliferative endometrium, Endometrial hyperplasia, Endometrial carcinoma