Adverse pregnancy and infant outcomes by COVID‐19 infection status before and during pregnancy

While prior studies have examined potential risks associated with COVID-19 infection during pregnancy, our study is one of the first to investigate potential risks associated with COVID-19 prior to pregnancy. We report significantly increased risk of hypertensive disorders of pregnancy (HDP), specifically preeclampsia/eclampsia, among pregnant women who had COVID-19 infection prior to pregnancy compared to those without COVID-19 in a statewide matched analyses after adjustment for covariates.COVID-19 infection during the first or second trimester was associated with increased risk for preeclampsia/eclampsia, placental abruption, and severe maternal morbidity (SMM) relative to those with no history of COVID-19.COVID-19 infection during the third trimester was associated with increased risk of preeclampsia/eclampsia, placental abruption, postpartum hemorrhage, and SMM (both including and excluding transfusion).

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Publication Details

Journal
Pregnancy
Published
2025-06-30
DOI
https://doi.org/10.1002/pmf2.70051
Primary Topic
COVID-19 Impact on Reproduction
Type
article
Field-Weighted Citation Impact
0.00

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article

Adverse pregnancy and infant outcomes by COVID‐19 infection status before and during pregnancy

Chun‐Che Wen, Kelly J. Hunt, Brian Neelon, Angela M. Malek et al.
Pregnancy
COVID-19 Impact on Reproduction
article

Adverse pregnancy and infant outcomes by COVID‐19 infection status before and during pregnancy

Chun‐Che Wen, Kelly J. Hunt, Brian Neelon, Angela M. Malek, Dulaney A. Wilson, Kalyan J. Chundru, Hermes Flórez, Mallory Alkis, Jeffrey E. Korte, John Pearce, Sarah Simpson, Julio Mateus, Erin Alsbrook, Veronica Spates
article en

Abstract

While prior studies have examined potential risks associated with COVID-19 infection during pregnancy, our study is one of the first to investigate potential risks associated with COVID-19 prior to pregnancy. We report significantly increased risk of hypertensive disorders of pregnancy (HDP), specifically preeclampsia/eclampsia, among pregnant women who had COVID-19 infection prior to pregnancy compared to those without COVID-19 in a statewide matched analyses after adjustment for covariates.COVID-19 infection during the first or second trimester was associated with increased risk for preeclampsia/eclampsia, placental abruption, and severe maternal morbidity (SMM) relative to those with no history of COVID-19.COVID-19 infection during the third trimester was associated with increased risk of preeclampsia/eclampsia, placental abruption, postpartum hemorrhage, and SMM (both including and excluding transfusion).

PregnancyVol. 1(4)
Medical University of South Carolina (US), Ralph H. Johnson VA Medical Center (US)
National Institutes of Health, National Heart, Lung, and Blood Institute
Good health and well-being
Openalex Percentile: Top 80%
COVID-19 Impact on Reproduction
DOIOpen Access PDFOpenAlex
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