Carbonic Anhydrase IX and Cyclooxygenase-2 Regulation in Renal Cell Carcinoma and Impact on Therapeutic Efficiency of Anti-CAIX CAR T cells
These findings suggest a regulatory interaction between CAIX and COX-2 levels, indicating that COX-2 inhibitors may diminish the efficacy of CAIX-targeted therapies and should be avoided in combination treatments.
Authors
- Najla Santos Pacheco de Campos (ORCID: https://orcid.org/0000-0002-2019-5947)
- Tiago Rodrigues (ORCID: https://orcid.org/0000-0003-1277-0224)
- Gabriela Sarti Kinker
- Laura Souza
- Eloah Rabello Suarez (ORCID: https://orcid.org/0000-0002-0521-1056)
- Tiago da Silva Medina (ORCID: https://orcid.org/0000-0001-8674-8842)
- Renata Schmieder Pivetta
Institutions
- AC Camargo Hospital (BR)
- Universidade Federal do ABC (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Current Topics in Medicinal Chemistry
- Published
- 2025-06-27
- DOI
- https://doi.org/10.2174/0115680266364293250613090952
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00