The Development of Inner Ear Membrane Analogues for Experimental Otorhinolaryngology
During the optimization of the mRWM fabrication protocol and the selection of suitable substrate components and cellular material, the model based on a thin Viscoll collagen membrane has been chosen as a substrate and primary human dermal fibroblasts and epithelial cells of the HaCaT line as a cellular material. The obtained experimental samples of mRWM represent a semipermeable membrane with living cells on the surface and are an alternative analog of the native structure, reproducing its geometric and morphofunctional characteristics. In addition, there has been demonstrated a method of using the for preclinical studies of electrophysical devices designed for accelerated passage of target substances through this membrane using electroporative and iontophoretic effects.
Authors
- С. В. Небогаткин (ORCID: https://orcid.org/0000-0002-9041-0729)
- V. S. Мischenko
- E S Yanyushkina
- Е. A. Vorotelyak (ORCID: https://orcid.org/0000-0001-5405-0212)
- O. S. Rogovaya (ORCID: https://orcid.org/0000-0003-4251-9372)
- Е. А. Шершунова (ORCID: https://orcid.org/0000-0001-7581-8008)
- N. L. Кunelskaya (ORCID: https://orcid.org/0000-0002-1001-2609)
- Andrei Riabinin (ORCID: https://orcid.org/0000-0002-7337-1166)
- Mikhail M. Ilyin (ORCID: https://orcid.org/0000-0002-0214-8573)
- A I Kryukov
- K I Pomanov
- V V Voyevodin
Institutions
- A. N. Nesmeyanov Institute of Organoelement Compounds (RU)
- Koltzov Institute of Developmental Biology (RU)
- Institute of Electrophysics (RU)
- Scientific Research Clinical Institute. L.I. Sverzhevsky (RU)
Publication Details
- Journal
- Sovremennye tehnologii v medicine
- Published
- 2025-06-30
- DOI
- https://doi.org/10.17691/stm2025.17.3.01
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.00