Capabilities of Human Biotissue Fluorescence Spectroscopy in the Wearable Multimodal Version

To demonstrate the capabilities of the wearable analyzers of the oxidative biotissue metabolism, pilot experimental investigations have been carried out involving 8 conditionally healthy volunteers. Parameters of microcirculatory-tissue systems (oxidative metabolism) were recorded with a modified multimodal wearable analyzer capable of measuring the skin fluorescence spectra in a wide range from 320 to 900 nm. Skin fluorescence was registered in the region of forehead, dorsal carpal surface, the volar surface of the distal phalanx of the middle finger, and the plantar surface of the distal phalanx of the first toe at a 365 nm wavelength of exciting irradiation.The conducted experiment has shown that despite the existing effect of biotissue hyperemia together with the level of melanin on the recorded fluorescence spectrum, the assessment of skin fluorescence intensity in dynamics and functional tests reflect changes in metabolic processes of biotissues and may be considered as a promising diagnostic criterion.