Successful Mesenchymal Stem Cell Therapy in A Patient with Ciprofloxacin Sensitivity

Objectives: Fluoroquinolones are frequently prescribed due to their wide range of antibacterial effects, ease of administration, and widespread availability. However, they are also the second most frequent antibiotics associated with drug allergies. Although it is effectiveness, the potential for causing severe allergic reactions may restrict the available treatment options. Mesenchymal stem cells have the potential to be used as therapeutic agents because of their ability to modulate the immune system and reduce inflammation. They have the potential to be candidates for the treatment of drug-induced hypersensitivity as they release bioactive substances that regulate the activity of immune cells. In this study, allogeneic mesenchymal stem cells were utilized as a therapeutic approach to address the patient's hypersensitivity to ciprofloxacin. Case Summary: Following cellular treatment, the patient's eosinophil cationic protein levels returned to a normal range, and there was a significant decrease in ciprofloxacin-specific IgE antibodies from 560 pg/ml to 50 pg/ml. No adverse effects were seen throughout the treatment. Practice Implications: According to our findings, mesenchymal stem cells have the ability to regulate the immune response in cases of drug-induced hypersensitivity. Additional research is necessary to comprehend the impact of cell treatments on the immune system.