Exploring the Antimicrobial and Anticancer Activities of Novel Copolyester Derived from Isophthaloyl Chloride and 4,4′-Biphenol

The copolyester PBHI was prepared from isophthaloyl chloride, 4,4′-biphenol and 2,5-hexanediol by means of solution polycondensation procedure. The solubility and inherent viscosity were measured for the synthesized polyester. The structure, composition and distribution of the repeat sequence in the polyester was ascertained by means of UV-visible, infrared and 1H NMR spectroscopy. The thermal stability and energy of activation for decomposition were probed by thermogravimetric analysis (TGA) and the transition temperatures in the melting of the polymer were scrutinized using differential scanning calorimetry (DSC) and the thermograms revealed a relatively higher melting temperature (Tm) and also displayed a two stage decomposition in the copolyester prepared. Wide angle X-ray diffraction (WAXD) and scanning electron microscopy (SEM) techniques were utilized to investigate the crystallinity and the morphology of the surface in the copolyester. The antimicrobial studies using well-diffusion method and in vitro cytotoxicity study using MTT method against HeLa cell line were carried out.