Dual‐Crosslinked Betaine‐Based Amphiphilic Hydrogel as a Promising Vitreous Substitute: Anti‐Adhesion, Anti‐Fouling, and Anti‐Cell Proliferation
Developing an ideal vitreous substitute remains a significant challenge in ophthalmic surgery. This study introduces a novel dual-crosslinked betaine-based amphiphilic polymer hydrogel (BAPHs) synthesized via in situ free radical copolymerization. The resulting BAPHs exhibit tunable viscoelasticity, intrinsic self-healing property, injectability, stable micromorphology, and optical transparency, all modifiable by adjusting the chemical cross-linker content. When tested in a vitrectomized rabbit model, the BAPHs demonstrated optimal optical properties, mechanical stability, and promising biocompatibility. These results suggest that the BAPHs offer a transformative approach to vitreous substitution, with the potential to overcome the limitations of current clinical materials, offering both structural and functional benefits.
Authors
- Yuting Cai (ORCID: https://orcid.org/0000-0002-1758-0086)
- Yun Tan (ORCID: https://orcid.org/0000-0002-9855-8234)
- Chuntai Liu (ORCID: https://orcid.org/0000-0001-9751-6270)
- Jianghua Li (ORCID: https://orcid.org/0000-0002-5753-7744)
- Yun Li (ORCID: https://orcid.org/0000-0001-8963-5819)
- Xingyuan Li (ORCID: https://orcid.org/0000-0002-3047-7219)
- Yi Zhang (ORCID: https://orcid.org/0009-0005-2839-0404)
- Jian Cao (ORCID: https://orcid.org/0000-0003-4747-4994)
- Xiaoyuan Zhou
Institutions
- Central South University (CN)
- Nanchang University (CN)
- Zhengzhou University (CN)
- Second Xiangya Hospital of Central South University (CN)
- Xinjiang University (CN)
Publication Details
- Journal
- Advanced Science
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1002/advs.202413455
- Citations
- 5
- Primary Topic
- Retinal and Macular Surgery
- Type
- article
- Field-Weighted Citation Impact
- 6.80
Funders
- National Natural Science Foundation of China
- Hunan Provincial Science and Technology Department
- Natural Science Foundation of Hunan Province
- Basic and Applied Basic Research Foundation of Guangdong Province