A Novel Synthetic Route of (Z)-Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate: A Key Intermediate of Apixaban

The objective of the present study to resolve the technical problem like long reaction time, low product yield for the synthetic method of Eliquis intermediate, (Z)-ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate and the inconsistency in the purity of product. Thus, a novel synthesis pathway for the Eliquis intermediate, (Z)-2-chloro-[(4-methoxyphenyl)hydrazono]ethyl acetate, which is a crucial precursor for apixaban is developed.