A Rare Case of Disseminated Histoplasmosis in a Postrenal Transplant Patient

Histoplasmosis is a fairly common fungal infection which usually remains asymptomatic in immunocompetent persons but can present systemically in immunocompromised patients. We report a case of a 37-year-old male patient who is postrenal transplant patient and presented with relatively nonspecific complaints including nausea, vomiting, headache, and giddiness for 4–5 days. Initially, the patient was treated with IV fluids, and routine workup was done. Ten days later, patient developed a fever with chills associated with irrelevant talks with altered sensorium. On detailed workup, high-resolution computed tomography of the thorax was suggestive of a soft-tissue nodular lesion 12 mm × 12 mm at the subpleural location of the right upper lobe with reactive mediastinal lymphadenopathy. endobronchial ultrasound (EBUS)-guided broncho-alveolar lavage (BAL) and biopsy were done and histopathological examination was suggestive of histoplasmosis and patient was diagnosed as disseminated histoplasmosis with involvement of the central nervous system and pulmonary system involvement. The patient was treated with liposomal amphotericin B at dose of 5 mg/kg/day OD for 14 days. The patient gradually improved after the initiation of treatment.