Cerebral small vessel disease and effects of intensive versus standard blood pressure treatment on cardiovascular outcomes and adverse events
In this posthoc analysis of SPRINT, adults with a higher WMHv were at a higher risk for adverse cardiovascular and cognitive outcomes. Among these adults, intensive blood pressure treatment reduced cardiovascular events, while its effects on the risk of cognitive impairment or dementia in this subgroup merit further study.
Authors
- Sarah A. Gaussoin (ORCID: https://orcid.org/0000-0003-0850-7888)
- Ilya M. Nasrallah (ORCID: https://orcid.org/0000-0003-2346-7562)
- Manjula Kurella Tamura (ORCID: https://orcid.org/0000-0001-5227-2479)
- Nicholas M. Pajewski (ORCID: https://orcid.org/0000-0002-4447-6196)
- Mallika Reddy
- R. Nick Bryan (ORCID: https://orcid.org/0000-0002-2327-4579)
- June Li (ORCID: https://orcid.org/0009-0007-6242-5839)
Institutions
- VA Palo Alto Health Care System (US)
- Wake Forest University (US)
- University of Pennsylvania (US)
- Stanford University (US)
Publication Details
- Journal
- Journal of Hypertension
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1097/hjh.0000000000004093
- Citations
- 1
- Primary Topic
- Cerebrovascular and Carotid Artery Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.52