Enhancing Surgical Wound Healing: A Synergistic Approach Using Coated Vicryl and Quercus Infectoria Galls in a Rat Model

Objective: taking care of wound healing, and warning of surgical line infection are important concern after surgical operation. Quercus infectoria Olivier Galls (Q.infectoria) stimulates healing of cutaneous wound through involvement in granulation tissue formation, collagen deposition and tissue remodeling by different way of application. Material and Method: eighteen adult healthy male rats with 200-300 gm of weight were used. Longitudinal skin incisional wounds were formed on the back region of each rat, they were divided into two groups; control group (n=9 with 3 replication for each duration) were subjected to suturing through the subcuticular closure with Vicryl, while treatment group (n=9 with 3 replication for each duration) were sutured with Vicryl suture that impregnated within the Q.infectoria extract solution. Result: The rate of wound contraction was faster in the treatment than the control group. Histopathological changes on 0, 7th and 14th days showed significant difference between control and treatment group depending on the rate of angiogenesis, intensity of granulation tissue and epidermis re-epithelization, and the amount of collagen fibers which were higher in the treatment group than control group. Conclusion: Coating Vicryl suture with Q.infectoria extract solution enhances the cutaneous wound healing process in the animal model and reducing post-operative complication and can be used as effective medical agent to inhibit the development of inflammations.