Effect of Dipeptidyl Peptidase-4 Inhibitor and angiotensin II type 1 receptor blocker on renal function in D-galactose induced Aging in male rats and possible relation between their effects.

Background: Aging induces structural alterations in the kidney and impairs its functionality. The progression of renal aging is intricately influenced by oxidative stress. Research has shown that plasma DPP-4 activity increases across various organs with aging. Additionally, heightened renin-angiotensin system activity during normal aging may contribute to chronic kidney disease (CKD) sequential progression. Objective: To evaluate potential synergistic effects of angiotensin II type 1 (Ang II type 1) receptor antagonists and DPP-4 inhibitors in D-galactose-induced aging in male rats, as well as their potential renoprotective effects. Materials and Methods: Thirty-five adult male albino rats were randomly divided into five groups: Group I (control), Group II (D-galactose), Group III (D-galactose + DPP-4 inhibitor), Group IV (D-galactose + Ang II type 1 receptor blocker), and Group V (D-galactose + DPP-4 inhibitor + Ang II type 1 receptor blocker). Results: Both of group III and IV provided substantial protection against D-galactose-induced renal damage (group II). Notably, combining both drugs (group V) resulted in enhanced renal protection compared to either drug alone, demonstrating their synergistic effect. Improved renal function was mediated through antioxidant mechanisms, evidenced by significant increase in tissue SOD level (p<0.01) along with significant decrease serum creatinine level (p<0.01). Conclusion: DPP-4 inhibitors and angiotensin II blocker combination is a promising therapeutic approach for age-related renal dysfunction.