Sequence-based CLEC7A rs3901533 gene Polymorphisms Linked to Iraqi COVID-19 Patients

Background: The genetic diversity of the hosts may have an impact on the clinical range of COVID-19 severity. Dectin-1, an integral component of the innate immune response to SARS-CoV-2, is encoded by the CLEC7A gene. Objectives: This study investigates the relationship between Iraqi patients' susceptibility to COVID-19 and CLEC7A rs3901533 (A/C) polymorphisms. Methodology: Twenty COVID-19 patients, twenty recovered people, and twenty healthy controls provided a total of sixty DNA samples. Using the sequencing method, the CLEC7A rs3901533 (A/C) polymorphisms were genotyped. Results: The frequencies of the A and C alleles were 45%, 52.5%, and 55%, respectively, in patients, recovered individuals, and controls, and 57.5%, 47.5%, and 45%, respectively. Among COVID-19 patients, the CC genotype was much more common (30%) than in controls (15%), indicating a strong correlation with higher susceptibility to the disease (P-value < 0.05). Conclusion: According to the results, the CC genotype of the CLEC7A rs3901533 polymorphism may be a genetic risk factor for heightened susceptibility to COVID-19. These findings demonstrate the potential of CLEC7A genotyping in predicting the course of disease and directing individualised treatment strategies.