A Novel Approach to Evaluating the Design of Pediatric Pharmacokinetic Studies Focused on Accurate Dose Selection
The ADS approach practically evaluates the precision in dose selection, providing a directly relevant decision criterion for designing pediatric pharmacokinetic studies and could be an alternative for power evaluation when the study is focused on determining doses using discrete tablet sizes.
Authors
- Elin M. Svensson (ORCID: https://orcid.org/0000-0002-0093-6445)
- Yuanxi Zou (ORCID: https://orcid.org/0000-0003-0547-390X)
- Jerry Nedelman (ORCID: https://orcid.org/0000-0002-0205-522X)
- Mats O. Karlsson (ORCID: https://orcid.org/0000-0003-1258-8297)
Institutions
- Uppsala University (SE)
- Radboud University Nijmegen (NL)
- TB Alliance (US)
- Radboud University Medical Center (NL)
Publication Details
- Journal
- Clinical Pharmacokinetics
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1007/s40262-025-01542-z
- Primary Topic
- Pharmaceutical studies and practices
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- United States Agency for International Development
- Bill and Melinda Gates Foundation
- Irish Aid
- Department of Foreign Affairs and Trade, Australian Government
- Bundesministerium für Bildung und Forschung
- Uppsala Universitet
- Foreign, Commonwealth and Development Office