Correlation Monocyte Count, High Density Lipoprotein Cholesterol Levels and Monocyte High Density Lipoprotein Cholesterol Ratio with hsCRP Levels in Hypertension Patient

Background: Hypertension is a condition which blood pressure in blood vessels increases chronically. Previous studies have shown that hypertension is associated with an inflammatory process involving innate and adaptive immune responses. Hypertension led to increased levels of several inflammatory markers such as Tumor Necrosis Factor-α (TNF-α), Interleukin-6 (IL-6) and C-Reactive Protein (CRP). Chronic inflammation is also characterized by an increase in the number of monocytes. Activation and spread of monocytes can be inhibited by High Density Lipoprotein Cholesterol (HDL-C). HDL-C can also inhibit the work of activated monocytes. Objective: Aim of this study was to determine the relationship between the number of monocytes, high density lipoprotein levels, and the ratio of monocytes to high-sensitivity C-reactive protein concentrations in a population of people with high blood pressure. Method: This study was conducted using a cross-sectional design in hypertensive patients who visited the heart disease and internal medicine polyclinic at Pertamina Hospital Cirebon with a total of 67 respondents with grade 2 hypertension according to JNC VII. Results: Correlation between hsCRP with Monocyte Count was positive but not significant (p=0,311; r=0,126), hsCRP and HDL-C has negative correlation (p=0,273; r=-0,136), hsCRP and monocyte HDL rasio also had no significant correlation (p=0,121; r=0,191) Conclusion: There was no correlation between hsCRP with monocyte count, hsCRP, and Monocyte HDL Ratio (MHR) (P>0.05).