Spatial Transcriptome Analysis of B7-H4 in Head and Neck Squamous Cell Carcinoma: A Novel Therapeutic Target for Anti-Immune Checkpoint Inhibitors
B7-H4 is a promising antibody-drug conjugate target in ICI-resistant HNSCC. IHC combined with TCs enabled the reliable assessment of B7-H4, given its co-localization with VTCN1 in IHC-positive areas and association with low-CD8<sup>+</sup> T-cells.
Authors
- Yuri Noda (ORCID: https://orcid.org/0000-0001-8041-0074)
- Masao Yagi (ORCID: https://orcid.org/0000-0002-9531-4787)
- Koji Tsuta
Institutions
- Kansai Medical University (JP)
Publication Details
- Journal
- Head and Neck Pathology
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1007/s12105-025-01815-w
- Citations
- 4
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 4.18