Salvianic acid A enhances anti-PD-1 therapy by promoting HEV-mediated stem-like CD8 T cells infiltration in TNBC
SAA significantly enhances the efficacy of anti-PD-1 therapy by promoting HEV-mediated stem-like CD8 T cells infiltration in TNBC. The combination of SAA and αPD-1 represents a promising therapeutic strategy that warrants further exploration in preclinical and clinical settings.
Authors
- Yan Luo (ORCID: https://orcid.org/0000-0001-7073-6150)
- Qu Zhang (ORCID: https://orcid.org/0000-0001-7224-0642)
- Xiaoming Ding (ORCID: https://orcid.org/0000-0002-9082-9191)
- Gai Liang (ORCID: https://orcid.org/0000-0003-1802-2606)
- Bo Luo (ORCID: https://orcid.org/0000-0002-1537-836X)
- Xiaomei Zhou
Institutions
- Wuhan Third Hospital (CN)
- Hubei Cancer Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1007/s00262-025-04116-x
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Clinical Specialty Discipline Construction Program of China