Diversity of mast cell subpopulations in the tumor microenvironment of colorectal cancer and their prognostic implications
This study reveals the functional heterogeneity of mast cell subpopulations in the CRC tumor microenvironment and their differential roles in tumor progression. Identification of mast cell subpopulation-specific marker genes provides new molecular targets for clinical diagnosis, prognostic prediction, and personalized immunotherapy in CRC.
Authors
- Guiyu Wang (ORCID: https://orcid.org/0000-0003-2501-5017)
- Tianyu Qiao
- Songtao Yu (ORCID: https://orcid.org/0000-0002-2804-9581)
- Chao Ding (ORCID: https://orcid.org/0000-0003-4451-740X)
- Wenyang Li (ORCID: https://orcid.org/0009-0003-4949-7759)
- Yaling Zhao (ORCID: https://orcid.org/0000-0003-0880-5594)
Institutions
- Harbin Medical University (CN)
- Heilongjiang Provincial Hospital (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1007/s00262-025-04119-8
- Citations
- 1
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China
- National Science and Technology Major Project