ELEMENTAL PROFILING OF TRIFOLIA LEAVES (MENYANTHES TRIFOLIATA L.) BY ICP-MS METHOD

Introduction. The need for systematic studies of the elemental composition of Menyanthes trifoliata is due to the need to ensure the quality and safety of pharmacopoeial raw materials in accordance with modern requirements. Aim. To carry out a analysis of the elemental composition of the leaves of Menyanthes trifoliata L., growing in the conditions of the swamp ecosystem of the Moscow region, using the ICP-MS method to assess compliance with the requirements of the GF RF, to identify the features of the accumulation of elements in specific environmental conditions. Matherial and Methods. M. trifoliata leaf samples were collected in July 2022 from bog ecosystem in Moscow region (55°86′N, 37°16′E). Sample preparation was performed according to OFS.1.1.0005.15. GF RF XV. Quantitative determination of 62 elements was performed by ICP-MS using ELAN DRC-e instrument. Statistical analysis included Pearson correlation analysis and cluster analysis. Results. Dominant concentrations of macroelements K > Ca > P > Mg > Na were established. Among essential microelements, Mn (215 μg/g) > Fe (111 μg/g) > Zn (53.2 μg/g) > Cu (9.77 μg/g) prevailed. The content of As (0.12 μg/g), Hg (0.015 μg/g) and Pb (0.16 μg/g) is below the maximum permissible concentrations of the Russian Pharmacopoeia by 4.2, 6.7 and 37.5 times, respectively. Cd concen-tration (2.87 μg/g) exceeds Russian Pharmacopoeia standards (1.0 μg/g) by 2.87 times. Correlation analysis revealed significant relationships between Ca and Sr