Engineered MoSe2-CuO interfaces for next-generation non-enzymatic glucose sensors

The development of highly sensitive, stable, and cost-effective glucose sensors is critical for non-enzymatic glucose detection. Traditional enzymatic sensors suffer from poor stability and operational constraints, while some non-enzymatic sensors are expensive, prone to interference, and have short detection ranges. To address these challenges, the MoSe2-CuO nanocomposite has been prepared as an excellent electrocatalyst for glucose oxidation, leveraging the synergistic properties of two-dimensional (2D) transition metal dichalcogenides and metal oxides. The MoSe2-CuO heterostructures show enhanced electrochemical response due to strong interfacial coupling, improved electron transport, and abundant active sites for glucose adsorption and oxidation. It is found that the MoSe2-CuO nanocomposite-based sensor possesses a fast response time of 3 s, a low limit of detection of 0.025 μM, a high sensitivity of 2406 μA mM−1 cm−2, and a broad linear range for glucose detection. Furthermore, the composite electrode demonstrates excellent selectivity against common interfering species and exhibits long-term stability, ensuring reliability for real-world applications. The practical applicability of the proposed sensor is also validated through glucose detection in a fruit juice sample. Thus, the MoSe2-CuO nanocomposite may pave the way for next-generation non-enzymatic glucose sensors with high efficiency, stability, and affordability for its real-life applications.