Canadian impact of CLSI aminoglycoside breakpoint changes for selected gram-negative bacteria
We evaluated the impact of recent revisions to the Clinical and Laboratory Standards Institute (CLSI) aminoglycoside breakpoints on susceptibility within Enterobacterales and <i>Pseudomonas aeruginosa</i> at a Canadian academic hospital. While the aminoglycoside breakpoint changes minimally affected overall susceptibility, the impact of these changes was notable within beta-lactamase producing Enterobacterales.
Authors
- Kevin Antoine Brown (ORCID: https://orcid.org/0000-0002-1483-2188)
- Taylor Laughlin
- Larissa Matukas
- Ellen G. Avery (ORCID: https://orcid.org/0000-0002-9094-1423)
- Elizabeth Leung (ORCID: https://orcid.org/0000-0002-7066-0886)
Institutions
- St. Michael's Hospital (CA)
- University of Toronto (CA)
- St Michael’s Hospital (IE)
- Public Health Ontario (CA)
- Unity Health Toronto
Publication Details
- Journal
- Antimicrobial Stewardship & Healthcare Epidemiology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/ash.2025.10035
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00