Biomimetic Implant Surface Functionalization with Concentrated Platelet-Rich Fibrin

Objective: With high long-term survival and success rates, implant-supported oral rehabilitation has progressively expanded the treatment options available to edentulous patients. However, osseointegration may be impacted by certain medical conditions. In order to enhance osseointegration and encourage fibrin adherence, surfaces with particular micro- and nanotopographies and biomimetic properties have been developed. Recently, there has been interest in a potential strategy that involves using the patient's autologous blood to functionalise the implant surface just prior to placement. The objective of this in vitro study is to analyse the physiochemical characterization of three commercially available dental implant surfaces and evaluate the interaction between the implant surface and C-PRF Materials and Methods: Three commercially available implants with different macro-morphology and surface treatments - Straumann® BLX Roxolid®, Zimmer® Trabecular MetalTM, and Laser-Lok® were analysed for physiochemical characterization and biofunctionalization using C-PRF Field emission scanning electron microscope (FESEM) Results: All the surfaces appeared visibly rough to varying degrees under FESEM with EDS. The topographies were qualitatively different for all three implant systems- Straumann® BLX Roxolid®, Zimmer® Trabecular MetalTM, and Laser-Lok® that were analysed, and showed different elemental compositions. Every dental implant immersed in C-PRF had a fibrin mesh covering it. Nonetheless, distinct noncontact regions were noted, and the fibrin orientation varied across all implant surfaces. Conclusions: There are notable differences in the initial interaction between the fibrin network and various implant surfaces. The therapeutic significance of these findings in the osseointegration process of dental implants requires further investigation.