Studies of All-<i>trans</i> Retinoic Acid Transport in the Eye
floRA is a reasonable surrogate for atRA binding to BSA, HDL, Apo A-I, and RBP4. Considering these proteins' relative serum and extravascular abundances, and their similar binding affinity to atRA, we predict that serum albumin is an important atRA carrier. Use of floRA in whole tissue tracer studies shows promise but requires further refinement.
Authors
- Melissa R. Bentley‐Ford (ORCID: https://orcid.org/0000-0002-9646-1420)
- Machelle T. Pardue (ORCID: https://orcid.org/0000-0001-8738-6839)
- M. G. Finn (ORCID: https://orcid.org/0000-0001-8247-3108)
- A. Thomas Read (ORCID: https://orcid.org/0000-0002-2764-6413)
- Maureen A. Kane (ORCID: https://orcid.org/0000-0002-5525-9170)
- Jianshi Yu (ORCID: https://orcid.org/0000-0002-4666-2435)
- Ankana Roy
- Saptarshi Chatterjee (ORCID: https://orcid.org/0000-0002-3334-1691)
Institutions
- University of Maryland, Baltimore (US)
- Georgia Institute of Technology (US)
- Emory University (US)
- The Wallace H. Coulter Department of Biomedical Engineering (US)
- Atlanta VA Health Care System (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1167/iovs.66.6.84
- Citations
- 1
- Primary Topic
- Retinoids in leukemia and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.81