The Impact of Human Cytomegalovirus among Children Patients with acute leukemia undergoing chemotherapy in Sana‘a City-Yemen

Human cytomegalovirus (HCMV) is a DNA virus categorized under the Herpesviridae family and is exclusively present in humans. This study aimed to identify HCMV antibodies and blood parameters in pediatric patients with pediatric leukemia patients with compromised immune systems in Sana‘a - Yemen. A cross sectional study was conducted to examine cytomegalovirus in pediatric leukemia cases are detecting HCMV antibodies and analyzing hematological parameters.in Sana’a city, Yemen, from June to October 2024. A total of 100 blood samples were collected from participants who had compromised immunity. Hematological parameters were evaluated and HCMV antibodies were alongside CMV detection using the ECLIA Cobas e 411 system. The majority of participants under the age of 12, 100% IgG positivity and this recent infection, 4% IgM positivity and this recent infection for HCMV in pediatric leukemia patients and the elevated WBC and PLT counts observed but no numerical data provided. These findings indicated that a high prevalence of HCMV antibodies in children with acute leukemia patients a significant increase of white blood cells (WBCs) and low platelet (PLT) counts in these patients.