Upconversion nanohybrids for NIR-induced photorepair of DNA etheno adducts
Here, we report NIR-triggered photorepair of DNA damages <i>via</i> photosensitization by using well-known upconversion nanohybrids consisting of ytterbium and erbium co-doped core-shell upconversion nanoparticles (UCs) and Rose Bengal (UC@RB). Specifically, two purine-derived etheno adducts (1,<i>N</i><sup>6</sup>-etheno-2'-deoxyadenosine (εdA) and 1,<i>N</i><sup>2</sup>-etheno-2'-deoxyguanosine (εdG)) have been used as proof of concept.
Authors
- Virginie Lhiaubet‐Vallet (ORCID: https://orcid.org/0000-0002-8205-8892)
- Laura Francés‐Soriano (ORCID: https://orcid.org/0000-0002-5630-4199)
- Paloma Lizondo‐Aranda (ORCID: https://orcid.org/0000-0002-8264-4146)
- Delia Bellezza (ORCID: https://orcid.org/0000-0003-1325-3755)
- Gemma M. Rodríguez‐Muñiz (ORCID: https://orcid.org/0000-0001-8989-2401)
- María González‐Béjar (ORCID: https://orcid.org/0000-0001-5434-4210)
Institutions
- Consejo Superior de Investigaciones Científicas (ES)
- Parc Científic de la Universitat de València (ES)
- Instituto de Tecnología Química (ES)
- Asociación de Investigación de la Industria Textil (ES)
- Universitat Politècnica de València (ES)
Publication Details
- Journal
- Nanoscale
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5nr01777g
- Citations
- 1
- Primary Topic
- Advanced Nanomaterials in Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.52
Funders
- Ministerio de Ciencia, Innovación y Universidades
- European Commission
- Generalitat Valenciana
- Universitat de València
- HORIZON EUROPE Framework Programme
- Agencia Estatal de Investigación
- Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital, Generalitat Valenciana