PEGylated W<sub>4.6</sub>N<sub>4</sub>/WO<sub>3</sub> nanoparticles as a near-infrared photothermal agent for effective cancer therapy
In recent years, near-infrared (NIR) light-sensitive photothermal agents (PTAs) with excellent photothermal conversion efficiency have shown great potential in enhancing the performance of advanced photothermal therapy (PTT). In this study, polyethylene glycol (PEG)-modified tungsten nitride/tungsten oxide nanoparticles (PEGylated W<sub>4.6</sub>N<sub>4</sub>/WO<sub>3</sub>-NPs) with heterojunction structures were designed and constructed. The PEGylated W<sub>4.6</sub>N<sub>4</sub>/WO<sub>3</sub>-NPs showed strong absorbance ability in the NIR window and photothermal conversion under 808 nm irradiation. The PEGylated W<sub>4.6</sub>N<sub>4</sub>/WO<sub>3</sub>-NPs exhibited good biocompatibility and efficient tumor ablation function. Therefore, the PEGylated W<sub>4.6</sub>N<sub>4</sub>/WO<sub>3</sub>-NPs can be used as a photothermal agent.
Authors
- Cong Wang (ORCID: https://orcid.org/0000-0001-6734-3196)
- Na Xu (ORCID: https://orcid.org/0000-0001-8546-1815)
- Jianping Li (ORCID: https://orcid.org/0000-0002-4859-1677)
- Rui Yang (ORCID: https://orcid.org/0000-0001-7679-9646)
- Hao Song (ORCID: https://orcid.org/0000-0003-0297-3562)
Institutions
- Wuhan University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Materials Chemistry B
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5tb00665a
- Citations
- 1
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.67
Funders
- Hubei Provincial Department of Education
- Wuhan University of Science and Technology