Association of Monocyte/HDL-Cholesterol Ratio and Other Inflammatory Markers with Carpal Tunnel Syndrome

Objective: Carpal tunnel syndrome (CTS) is the most common compression neuropathy.Although its etiology is idiopathic, inflammatory processes are frequently implicated.Various inflammatory parameters obtained from complete blood count data are helpful in the diagnosis and prognosis of many inflammatory diseases.However, there is no consensus in the literature regarding the association between CTS and serum inflammatory markers.This study aimed to assess whether there were significant differences in various inflammatory markers between patients with severe CTS and healthy controls. Methods:In this retrospective study, we compared 40 patients who had unilateral severe CTS which is diagnosed by clinic symptoms and positive electrodiagnostic tests (EDT) with 42 healthy patients.We investigated serum inflammatory markers such as the monocyte/ HDL-cholesterol ratio (MHR), red blood cell distribution width (RDW), mean platelet volume (MPV), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and monocyte/lymphocyte ratio (MLR) in patients with unilateral severe CTS compared to a control group.Results: No significant difference was observed between the two groups in WBC, CRP, SED values analysed for the presence of active inflammation.No significant difference was observed between the two groups in the analysed parameters PLT, NEU, LYM, MON, and HDL (p>0.05).When inflammatory parameters were analysed, no difference was observed between the two groups in RDW, MPV, HDL, NLR, PLR, and MLR values (p>0.05). Conclusion:No significant association was found between serum inflammatory markers in the two groups, suggesting that inflammation in CTS may be localized.