The CXCL16/CXCR6 axis is linked to immune effector cell-associated neurotoxicity in chimeric antigen receptor (CAR) T cell therapy
Our findings implicate the CXCL16/CXCR6 axis in the recruitment of cytotoxic CAR CD4 + T cells to the central nervous system (CNS) during ICANS. This interaction may be linked to neuroinflammatory processes and severity stratification in ICANS pathogenesis. These results provide a mechanistic rationale for exploring CXCL16/CXCR6 as a potential biomarker and therapeutic target in CAR T cell-associated neurotoxicity.
Authors
- Matthias Stelljes
- Annalen Bleckmann (ORCID: https://orcid.org/0000-0001-5809-9507)
- Kornelius Kerl (ORCID: https://orcid.org/0000-0002-5676-8102)
- Heinz Wiendl (ORCID: https://orcid.org/0000-0003-4310-3432)
- Georg Lenz (ORCID: https://orcid.org/0000-0002-4728-1693)
- Astrid Jeibmann (ORCID: https://orcid.org/0000-0003-3759-3164)
- Carolin Krekeler (ORCID: https://orcid.org/0009-0000-1808-5928)
- Oliver Grauer
- Andreas Schulte‐Mecklenbeck (ORCID: https://orcid.org/0000-0003-3855-4706)
- Christian Reicherts
- Louisa Müller‐Miny (ORCID: https://orcid.org/0000-0001-5689-585X)
- Phyllis F. Cheung (ORCID: https://orcid.org/0000-0002-0075-5679)
- Georgia Antonopoulou (ORCID: https://orcid.org/0000-0001-9681-4890)
- Simon Call
- I‐Na Lu (ORCID: https://orcid.org/0000-0002-3845-7386)
- Gerd Meyer zu Hörste (ORCID: https://orcid.org/0000-0002-4341-4719)
Institutions
- German Cancer Research Center (DE)
- University Medical Center Freiburg (DE)
- University Hospital Münster (DE)
- Essen University Hospital (DE)
- University of Duisburg-Essen (DE)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1186/s13073-025-01498-6
- Citations
- 6
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 6.27
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg