Tocotrienol-Enriched Beverage Enhances Psychological Well-Being, Antioxidant Defense, and Genomic Stability in Older Adults: A Randomized Controlled Trial

<b>Background:</b> This study investigates the effects of a tocotrienol-enriched drink on oxidative damage and genomic stability in older adults over a 6-month period. <b>Methods:</b> A total of 67 participants (27 males and 40 females, mean age 60.45 ± 5.75 years) were enrolled in this double-blinded, two-arm, parallel randomized controlled trial. Baseline, mid-point, and end-point assessments were conducted to monitor various health parameters. Significant Group × Time interaction effects were observed for several key outcomes. <b>Results:</b> Group A demonstrated significantly better improvements in QOL-Psychological (<i>p</i> = 0.014, Partial Eta Squared = 0.153), suggesting a beneficial impact of tocotrienol supplementation on mental well-being. Additionally, Group A showed more favorable trends in TNF-α (<i>p</i> = 0.04), T-SOD (<i>p</i> = 0.04), catalase (<i>p</i> = 0.02), and telomerase (<i>p</i> = 0.02), suggesting potential antioxidant and genomic stability improvements over time. <b>Conclusions:</b> In a nutshell, tocotrienol supplementation may exert beneficial effects on psychological well-being, oxidative stress modulation, and genomic stability in aging populations.