Investigating the Effect of Hemoperfusion Therapy on Laboratory and Clinical Factors in COVID-19 Patients: A Cross-Sectional Study

Background: With the epidemic of the emerging COVID-19 disease in the world in 2019 and the lack of a definitive and effective treatment for it, medical science practically faced a new challenge, this study aimed to investigation the effect of hemoperfusion therapy on laboratory and clinical factors in COVID-19 patients. .Materials & Methods: In this cross-sectional study, 49 patients with severe COVID-19, who had indications for hemoperfusion were examined in 2020-2021.The patients underwent four hemoperfusion sessions after inserting a vascular catheter and preparing a special filter.Changes in laboratory and clinical factors before and after each hemoperfusion session were carefully recorded, and the data were analyzed using SPSS software. Findings:The results of the study showed that the average age of the patients was 55.5 13.9 years.Changes in the patients' blood oxygen saturation levels after each hemoperfusion session showed a statistically significant improvement trend, the average values before and after the first session were 86.77.2% and 88.55.7%,respectively, indicating a significant increase (p= .009).Also, the inflammatory factor CRP (C-reactive protein) and blood platelet levels were significantly reduced after each hemoperfusion session. Conclusion:This study showed that hemoperfusion could improve patients' blood oxygen saturation values without causing any special complications and could also have a clear effect on clearing inflammatory factors and CRP from the blood.