TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis
TRAF3IP2-AS1 deficiency drives necroptosis in pancreatic cancer cells to engender a prometastatic immunosuppressive niche mediated by TGFβ1 production, providing mechanistic understanding of necroptosis and therapeutic strategies for treating liver metastasis.
Authors
- Cheng‐Yu Liao (ORCID: https://orcid.org/0000-0001-7221-7522)
- Zuwei Wang
- Yi-Feng Tian
- Yu Pan (ORCID: https://orcid.org/0000-0002-7417-4551)
- Cai‐Feng Lin (ORCID: https://orcid.org/0000-0001-9869-1281)
- Ge Li (ORCID: https://orcid.org/0009-0004-2709-8148)
- Qiao-Wei Li
- Shi Chen (ORCID: https://orcid.org/0000-0002-8207-7479)
- Xiaoyan Lin
- Haoxiang Zhang (ORCID: https://orcid.org/0000-0002-6302-0901)
- Jian-Fei Hu (ORCID: https://orcid.org/0009-0002-0595-0518)
- Yongding Wu (ORCID: https://orcid.org/0009-0000-4874-2589)
- Shun-Cang Zhu
- Zhi-Yuan Li (ORCID: https://orcid.org/0009-0007-9619-6317)
- Hong-Yi Lin (ORCID: https://orcid.org/0000-0002-4623-0819)
- Xiaoxiao Huang (ORCID: https://orcid.org/0000-0003-1083-2217)
- Cheng-Ke Xie (ORCID: https://orcid.org/0000-0002-7986-7226)
- Yin-Hao Chen
Institutions
- Fujian Medical University (CN)
- Mengchao Hepatobiliary Hospital (CN)
- Fujian Provincial Hospital (CN)
- Union Hospital (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1158/0008-5472.can-24-4784
- Citations
- 7
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 6.55