Efficacy of Microneedling in the Treatment of Acne Scars

Aims: This review evaluates the clinical efficacy of microneedling (MN) in treating atrophic acne scars, both as a monotherapy and in combination with platelet-rich plasma (PRP), topical agents, and radiofrequency energy. Methods: A total of 28 peer-reviewed clinical studies published between 2020 and 2025 were included. Articles were selected through a manual search of academic databases and screened for relevance, clinical applicability, and methodological clarity. Eligible studies included randomized controlled trials, cohort analyses, and comparative studies involving human subjects with acne scars treated using microneedling. Results: Microneedling as a standalone therapy consistently led to improvements in scar depth, skin texture, and patient satisfaction. Combination therapies with PRP or topical agents like hyaluronic acid, insulin, and phenytoin enhanced these effects, offering faster healing and improved outcomes. Radiofrequency-assisted microneedling (MNRF) demonstrated superior efficacy in deeper scars. The procedure showed strong safety and tolerability across different skin types, including Fitzpatrick types IV–VI. Patient-reported outcomes, such as reduced pain and improved quality of life, were also favorable. Conclusions: Microneedling is a safe, versatile, and effective modality for acne scar treatment. Its adaptability to combination therapies and suitability for diverse skin types support its ongoing integration into aesthetic dermatology.