Zoledronic acid as an uncommon cause of anterior uveitis – a case report

Aims: Purpose of this case report is to increase awareness of a rare zoledronic acid side effect which is acute anterior uveitis. We would like to educate both clinicians and patients about possible ocular symptoms that can occur after zoledronic acid administration. As an effect when patients develop these symptoms, they can get optimal medical care as soon as possible and minimize the risk of severe ocular complications. Case Description: We report a case of an unilateral acute anterior uveitis in a 69 years old woman with osteoporosis secondary to breast cancer treatment who presented with flu-like symptoms accompanied by visual symptoms such as redness, pain and foreign body feeling in the right eye after receiving zoledronic acid infusion. Other causes of uveitis were excluded and after proper treatment symptoms reduced. Outcomes: The inflammation resolved within two weeks of treatment, with no recurrence or long-term complications during follow-up. Posterior synechiae were successfully released, and visual acuity returned to baseline. Conclusions: Although the risk of acute anterior uveitis after zoledronic acid infusion is low, it is essential that patients receiving this kind of treatment were properly informed about possible ocular side effects and need for ophthalmological visit if any eye symptoms occur to ensure early diagnosis and prompt accurate treatment.