Asymptomatic Bacteriuria in Kidney Transplant Recipients: Always Not to Treat?
Asymptomatic bacteriuria (ASB) is a very frequent condition in kidney transplant recipients (KTRs). Guidelines advise against screening and treatment of ASB beyond the first month after renal transplantation. Here, we report the case of a 40-year-old female KTR with untreated ASB complicated with allograft pyelonephritis with urosepsis and acute kidney injury. The reported case highlights that ASB remains a grey area in the management of KTRs (after the first month), and there is a need for new ad hoc studies to identify which patients should be screened and eventually treated. Until new findings are available, it is suggested not to treat KTRs with ASB; however, if ASB is detected, stricter monitoring and non-antibiotic prophylaxis are necessary to favor prevention or prompt therapy of severe urinary tract infections.
Authors
- Luigi Di Martino (ORCID: https://orcid.org/0000-0002-9001-4726)
- Carlo Garofalo (ORCID: https://orcid.org/0000-0001-9362-0281)
- Roberto Minutolo (ORCID: https://orcid.org/0000-0001-5686-2089)
- Ilaria Fava (ORCID: https://orcid.org/0009-0001-5489-9643)
- Silvio Borrelli (ORCID: https://orcid.org/0000-0002-4414-4597)
- Francesca Cinone
- Antonio Russo (ORCID: https://orcid.org/0000-0002-4224-5343)
- Raffaele Prestano
- Chiara Ruotolo (ORCID: https://orcid.org/0000-0001-5437-5711)
- Luca De Nicola (ORCID: https://orcid.org/0000-0001-8532-0182)
- Concetta Altruda
- C. Nardelli (ORCID: https://orcid.org/0009-0000-9202-9414)
- Maria Federica Feliciano (ORCID: https://orcid.org/0009-0000-9502-2111)
Institutions
- University of Campania "Luigi Vanvitelli" (IT)
- University of Campania "Luigi Vanvitelli" (IT)
Publication Details
- Journal
- Kidney and Dialysis
- Published
- 2025-06-30
- DOI
- https://doi.org/10.3390/kidneydial5030028
- Primary Topic
- Urinary Tract Infections Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00